Publications

Key Publications

• Lee SE (Co-first), Park S, Kang R, Lee T, Yu WJ, Chang S, Park JC. Hippocampal tau-induced GRIN3A deficiency in Alzheimer’s disease. FEBS Open Bio. 2024 Oct 13. doi: 10.1002/2211-5463.13904
• LEE SE, Chang S. nArgBP2 together with GKAP and SHANK3 forms a dynamic layered structure. Front. Cell. Neurosci. 2024 Jan 19; 18:1354900. doi: 10.3389/fncel.2024.1354900
• Rueda-Carrasco J, Sokolova D, Lee SE (Co-first), Childs T, Jurčáková N, Crowley G, De Schepper S, Ge J, Lachica J, Toomey C, Freeman O, Hardy J, Barnes S, Lashley T, Stevens B, Chang S and Hong S. Microglia-synapse engulfment via PtdSer-TREM2 ameliorates neuronal hyperactivity in Alzheimer’s disease models. EMBO J. 2023 Aug 14;e113246. doi: 10.15252/embj.2022113246
• Lee SE (Co-first), Park SH, Jeon JH, Lee JH, Itakura E, Chang S, Lee MJ, Chio WH. Formation of aggresomes with hydrogel-like characteristics by proteasome inhibition. BBA-Gene Regul Mech. 2023 Mar 28;1866(2):194932. doi: 10.1016/j.bbagrm.2023.194932
• Cho E, Lee SE (Co-first), Lee U, Goh Y, Jeong S, Choi J, Jeong WK, Chang S. Biomolecular condensate assembly of nArgBP2 tunes its functionality to manifest the structural plasticity of dendritic spines. Exp. Mol. Med. 2023 Jan 4.  doi : 10.1038/s12276-022-00918-6
• Lee SE, Cho E, S Jeong, Y Song, S Kang, Chang S. SGIP1α, but Not SGIP1, is an Ortholog of FCHo Proteins and Functions as an Endocytic Regulator. Front. Cell. Dev. Biol. 2021;9:801420. doi: 10.3389/fcell.2021.801420
• Lee SE, Kim Y, Hang J, Park H, Lee U, Na M, Jeong S, Chung C, Cestra G, Chang S. nArgBP2 regulates excitatory synapse formation by controlling dendritic spine morphology. Proc. Natl. Acad. Sci. USA, 2016, Jun 14;113(24):6749-54. doi: 10.1073/pnas.1600944113

Full-List

2025

• Choi H, Kim HJ, Lee SE, Song HH, Kim J, Han J, Jeong JH, Lee DY, Chang S, Mook-Jung I. 25-Hydroxycholesterol modulates microglial function and exacerbates Alzheimer’s disease pathology: mechanistic insights and therapeutic potential of cholesterol esterification inhibition. J Neuroinflammation. 2025 Feb 25;22(1):50. doi: 10.1186/s12974-025-03357-y

2024

• Won J, Kim J, Kim J, Ko J, Park C, Jeong B, Lee SE, Jeong H, Kim SH, Park H, So I, Lee HH. Cryo-EM structure of the heteromeric TRPC1/C4 channel. Nat. Struct.Mol.Biol. 2024 Oct 30. doi: 10.1038/s41594-024-01408-1
• Lee SE (Co-first), Park S, Kang R, Lee T, Yu WJ, Chang S, Park JC. Hippocampal tau-induced GRIN3A deficiency in Alzheimer’s disease. FEBS Open Bio. 2024 Oct 13. doi: 10.1002/2211-5463.13904
• Park JC, Han JW, Lee W, Kim J, Lee SE, Lee D, Choi H, Kang YJ, Diep YN, Cho H, Kang R, Lee J, Choi M, Im SW, Kim JI, Mook-Jung I. Microglia Gravitate toward Amyloid Plaques Surrounded by Externalized Phosphatidylserine via TREM2. Adv. Sci. 2024 Jul 09. doi: 10.1002/advs.202400064
• Kim DK, Suh K, Park J, Lee SE, Han J, Chang S, Kim Y, Mook-Jung I. FGFR3 drives Aβ-induced tau uptake. Exp. Mol. Med. 2024 Jul 01. doi: 10.1038/s12276-024-01274-3
• LEE SE, Chang S. nArgBP2 together with GKAP and SHANK3 forms a dynamic layered structure. Front. Cell. Neurosci. 2024 Jan 19; 18:1354900. doi: 10.3389/fncel.2024.1354900

2023

• Rueda-Carrasco J, Sokolova D, Lee SE (Co-first), Childs T, Jurčáková N, Crowley G, De Schepper S, Ge J, Lachica J, Toomey C, Freeman O, Hardy J, Barnes S, Lashley T, Stevens B, Chang S and Hong S. Microglia-synapse engulfment via PtdSer-TREM2 ameliorates neuronal hyperactivity in Alzheimer’s disease models. EMBO J. 2023 Aug 14;e113246. doi: 10.15252/embj.2022113246
• Lee SE (Co-first), Park SH, Jeon JH, Lee JH, Itakura E, Chang S, Lee MJ, Chio WH. Formation of aggresomes with hydrogel-like characteristics by proteasome inhibition. BBA-Gene Regul Mech. 2023 Mar 28;1866(2):194932. doi: 10.1016/j.bbagrm.2023.194932
• Cho E, Lee SE (Co-first), Lee U, Goh Y, Jeong S, Choi J, Jeong WK, Chang S. Biomolecular condensate assembly of nArgBP2 tunes its functionality to manifest the structural plasticity of dendritic spines. Exp. Mol. Med. 2023 Jan 4.  doi : 10.1038/s12276-022-00918-6

2014 - 2022

• Nguyen YT, Kim C, Kim HI, Kim Y, Lee SE, Chang S, Ha NY, Cho NH. An Alternative Splicing Variant of the Mixed-Lineage Leukemia 5 Protein Is a Cellular Adhesion Receptor for ScaA of Orientia tsutsugamushi. mBio 2022 Dec 21;e0154322. doi: 10.1128/mbio.01543-22
• Lee SE, Cho E, S Jeong, Y Song, S Kang, Chang S. SGIP1α, but Not SGIP1, is an Ortholog of FCHo Proteins and Functions as an Endocytic Regulator. Front. Cell. Dev. Biol. 2021;9:801420. doi: 10.3389/fcell.2021.801420
• Choi J, Lee SE, Lee Y, Cho E, Chang S, Jeong WK. DXplorer: A Unified Visualization Framework for Interactive Dendritic Spine Analysis using 3D Morphological Features. IEEE Trans Vis Comput Graph 2021 Sep 30; vol. 29, no. 2, pp. 1424-1437. doi: 10.1109/TVCG.2021.3116656
• Kim G, Lee SE, Jeong S, Lee J, Park D, Chang S. Multivalent electrostatic pi-cation interaction between synaptophysin and synapsin is responsible for the coacervation. Mol Brain 2021;14:137. doi: 10.1186/s13041-021-00846-y
• Lee U, Choi C, Ryu SH, Park D, Lee SE, Kim K, Kim Y, Chang S. SCAMP5 plays a critical role in axonal trafficking and synaptic localization of NHE6 to adjust quantal size at glutamatergic synapses. Proc. Natl. Acad. Sci. U S A. 2021 Jan 12;118(2):e2011371118.doi: 10.1073/pnas.2011371118
• Park D, Wu Y, Lee SE, Kim G, Jeong S, Milovanovic D, Chang S, De Camilli P. Cooperative function of Synaptophysin and Synapsin in the generation synaptic vesicle-like clusters in non-neuronal cells. Nat.Commun. 2021 Jan 11;(12)263.doi: 10.1038/s41467-020-20462-z
• Lim S, Park H, Lee SE, Chang S, Sim B, Ye J.C. CycleGAN with a Blur Kernel for Deconvolution Microscopy: Optimal Transport Geometry. IEEE Transactions on Computational Imaging 2020;6:1127 – 1138. doi: 10.1109/TCI.2020.3006735
• Lee SE, Jeong S, Lee U, Chang S. SGIP1α functions as a selective endocytic adaptor for the internalization of synaptotagmin 1 at synapses. Mol Brain. 2019 May 3;12(1):41. doi: 10.1186/s13041-021-00846-y
• Lee SE, Kim JA, Chang S. nArgBP2-SAPAP-SHANK, the core postsynaptic triad associated with psychiatric disorders. Exp Mol Med. 2018 Apr 9;50(4):2. doi: 10.1038/s12276-017-0018-5
• Song JJ, Oh SM, Kwon OC, Wulansari N, Lee HS, Chang MY, Lee E, Sun W, Lee SE, Chang S, An H, Lee CJ, Lee SH. Cografting astrocytes improves cell therapeutic outcomes in a Parkinson's disease model. J Clin Invest. 2018 Jan 2;128(1):463-482. doi: 10.1172/JCI93924
• Lee SE, Chang S. nArgBP2 as a hub molecule in the etiology of various neuropsychiatric disorders. BMB Rep. 2016 Sep;49(9):457-8. doi: 10.5483/BMBRep.2016.49.9.138
• Lee SE, Kim Y, Hang J, Park H, Lee U, Na M, Jeong S, Chung C, Cestra G, Chang S. nArgBP2 regulates excitatory synapse formation by controlling dendritic spine morphology. Proc. Natl. Acad. Sci. USA, 2016, Jun 14;113(24):6749-54. doi: 10.1073/pnas.1600944113
• Kim Y, Lee SE, Park J, Kim M, Lee B, Hwang D, Chang S. ADP-ribosylation factor 6 (ARF6) bidirectionally regulates dendritic spine formation depending on neuronal maturation and activity.  J Biol Chem. 2015 Mar 20;290(12):7323-35.doi : 10.1074/jbc.M114.634527
• Zhao H, Kim Y, Park J, Park D, Lee SE, Chang I, Chang S. SCAMP5 plays a critical role in synaptic vesicle endocytosis during high neuronal activity. J. Neurosci., 2014 34(30): 10085-10095. doi : 10.1523/JNEUROSCI.2156-14.2014